In addition, phosphorylated EGFR was expressed in the distal tubules and collecting duct of renal tissue of patients with ADPKD (Fig. 3), but not in glomeruli, whereas expression of phosphorylated ErbB2 and phosphorylated ErbB4 was not detected along the nephron (Table 4). This evidence concerns the gene ERBB4 and autosomal dominant polycystic kidney disease.