In the animal model of atherosclerosis (ApoE knockout mice, ApoEko), knockout of FXI reduced peripheral atherosclerosis by up to 33%.29, 30In another animal study, low-density lipoprotein receptor knockout (Ldlr−/−) mice combined with high-fat diet were treated with anti-FXI antibody (14E11) or FXI ASO. This evidence concerns the gene LDLR and atherosclerosis.