F10 and atrial fibrillation: It was shown in a cohort study that in long-term follow-up, the FXIa level in circulating blood has been associated with poor prognosis such as IS and cardiovascular death in AF patients on anticoagulants.48Recently, the FXIa inhibitor asundexian at two doses (20 and 50 mg daily) showed lower bleeding rates than the active comparator, the FXa inhibitor apixaban 5 mg, in a phase II trial in AF at risk for stroke.