However, it still remains to be further investigated to what extent inhibition of FXI(a) is equally or more effective than established direct oral anticoagulants (DOACs) to prevent thrombotic events and if they could improve long-term prognosis of AF.49Current clinical studies testing the efficacy and safety of different types of FXI inhibitors, or FXI-lowering agents, is discussed further on in this article. The gene discussed is F11; the disease is atrial fibrillation.