In animal studies, human amyloid precursor protein (hAPP) transgenic mice from line J20 (hAPP-J20 mice) are used to establish the AD model, and the results have shown that coagulation factors are involved in the metabolism of Aβ,18, 19which can lead to the activation of FXII, resulting in FXI activation and thrombin generation, ultimately leading to a prothrombotic environment that contributes to the development of AD. Here, APP is linked to Alzheimer disease.