Salomon et al reported similar incidences of AMI in patients with severe FXI deficiency and the general population and inherited FXI deficiency seems to be not protective against AMI.46Results from the Risk of Arterial Thrombosis in Relation to Oral Contraceptives (RATIO) case-control study showed that high levels of FXI are associated with IS, but are not or to a lesser extent associated with MI, in young women.47These data suggest that the contribution of FXI in thrombosis varies between vascular beds and sex. The gene discussed is F11; the disease is Venous thrombosis.