TFPI and cardiovascular disorder: Numerous polymorphisms of TFPI have been studied over the last decades that in part correlate with increased risk of cardiovascular disease,36,37but sometimes only shown to be related to altered TFPI plasma levels, but not to an increased risk for CHD.38, 39, 40However, studies reporting blood concentrations of coagulation should be carefully interpreted, since lower circulating levels could reflect both reduced production or increased consumption (or vice versa).