HAVCR2 and nasopharyngeal carcinoma: Univariate analysis showed that TIM-3/TIGIT co-expression (hazard ratio [HR] 6.445, 95% confidence interval [CI] 1.839–112.541; P ═ 0.011), TIM-3/2B4 co-expression (HR 8.601; 95% CI 1.101–67.205; P ═ 0.04), age (HR 3.816, 95% CI 1.032–14.115; P ═ 0.045), and smoking (HR 3.823, 95% CI 1.343–10.882; P ═ 0.012) were risk factors for OS in NPC patients (Table 2).