CD40LG and dengue disease: However, these examples have either included laboratory generated data that are not typically available to clinicians in resource limited settings in real-time (e.g., anti-dengue IgG/IgM, viral load, host genetic polymorphisms, single cell RNAseq data [13]), or used an outcome such as “severe dengue” which has limited clinical value because of its subjective definition and low event rate [12,14].