VEGFA and neoplasm: Moreover, we used subcutaneous tumor model of xenograft in nude mice (tumor growth is shown in S1 Fig) to assess the VEGFA expression level by Western blotting, we found that LAMP2A knockdown significantly inhibited VEGFA expression in tumors from the shLAMP2A MDA-MB-436 implanted mice, compared with tumors from the negative MDA-MB-436 implanted mice, while LAMP2A overexpression significantly promoted VEGFA expression in tumors from the LAMP2A MDA-MB-436 implanted mice, compared with tumors from the control MDA-MB-436 implanted mice (Fig 5D).