PVR and neoplasm: T-cell immunoreceptor with immunoglobulin and tyrosine–based inhibitory motif domain belongs to the family of poliovirus receptors (PVRs) that competes with CD226, which is the co-stimulatory receptor of T cells and NK cells, by binding to CD112 and CD155 (PVR) expressed on antigen-presenting cells (APCs) and tumor cells.