ESR1 and neoplasm: The TF genes PBX1 has been found to possess multiple functions relevant to cell development and has been associated with tumor agents and COVID-19 [16,86], MEIS1 has been identified as the targeted agent of SARS-CoV-2 [16,87], ESR1 has been noted to act as an antiviral signature that disrupts the viral membrane of the SARS-CoV-2 protein [88].