S100A8 and gastric cancer: The reasons for such large difference in risk estimates are not fully understood, but may reflect differences in the sero-prevalence of H. pylori antigens which were generally higher in Asian populations than in European populations (CagA: 71–89% in Asians vs 45–50% in Europeans; HP1564: 65–85% in Asian vs 52–68% in Europeans), indicating potentially a relatively more important role of other factors in the aetiology of gastric cancer in Chinese populations.