In numerous unbiased proteomic studies,VGF (nonacronymic) hasbeen strongly linked to neurodegenerative diseases, including Alzheimer’sdisease (AD), as both a potential therapeutic target and biomarkerof cognitive status and disease pathogenesis.1−4 Chromogranin A (CHGA) has alsobeen strongly linked to AD, with its immunoreactivity to amyloid plaquepathology5 and potential as a biomarkerthat differentiates AD from controls.6 VGFand CHGA are members of the granin family of neuropeptides, acidicsecretory proteins,7 that also includethe Secretogranins-1, -2, -3, and -5 (SCG-1, -2, -3, and -5). The gene discussed is CHGB; the disease is Alzheimer disease.