It is possible that the peculiar role of sex hormones (androgen and estrogen) in the development of melanomas, as well as the complex intracellular mechanisms regulated by these 2 molecules, could explain the different PRAME expression observed in females and males.45,46 To conclude, the data here obtained indicate that PRAME is a useful tool for the appropriate diagnosis of MBML-H&N and MM-H&N. Here, PRAME is linked to melanoma.