Moreover, a drop in the conversion of [1‐13C] α‐ketoglutarate to [1‐13C]‐Glu was also observed in the same orthotopic glioma model, which was correlated with a drop in the activity and expression of several enzymes (BCAT1, ASTI1/2, GDH1/2) that catalyze the α‐ketoglutarate‐to‐Glu conversion, which is related to their 2HG‐induced promoter methylation and silencing.17 Here, GLUD1 is linked to central nervous system cancer.