IDH2 and Alpha-thalassemia: Ahn et al conducted a study in which gliomas with IDH and tumor protein 53 (TP53) mutations and alpha‐thalassemia/mental retardation X‐linked (ATRX) loss were found to be clustered according to their shared imaging features, including a poor definition of enhancing margin, high ADC values, and a higher proportion of T2 hyperintense lesions.104