Interestingly, the significantly improved survival in CRC patients with high NRG1 mRNA levels was observed in patients with higher than median levels of the expression of ERBB3, encoding a NRG1 receptor, suggesting that functional NRG1-ERBB3 signaling may underlie the beneficial prognosis in CRC (Fig. S9A). Here, NRG1 is linked to colorectal carcinoma.