Interestingly, we observed increased mRNA expression of both Ereg and Nrg1 in intestinal tumors of Apcmin mice, which model early CRC by developing multiple adenomas throughout the length of the intestine, owing to Apc loss-mediated constitutively active Wnt signaling (Jackstadt and Sansom, 2016) (Fig. S8A). Here, NRG1 is linked to adenoma.