Previous findings reported that DNMT3A mutations had a significant association with NPM1 and IDH1/IDH2 mutations, of which ~60% of DNMT3Amut cases having NPM1, and more often (~30%) displaying a significant co‐mutation pattern with NPM1 and FLT3‐ITD mutations, and had a mutually exclusive relationship with CEBPA mutations in AML patients.18, 19, 20. The gene discussed is NPM1; the disease is acute myeloid leukemia.