An analysis of 104 patients with DNMT3A‐mutated AML led by Narayanan et al.38showed that high DNMT3A VAF was associated with more inferior OS and EFS, but had no impact on CR rate in univariable analyses, but in multivariable analyses, the adverse effect of DNMT3AHigh only on OS but not on EFS in the CN‐AML subset. The gene discussed is DNMT3A; the disease is acute myeloid leukemia.