DNMT3A and Increased total leukocyte count: For biological features, we observed that DNMT3AHigh patients at diagnosis had a significantly higher WBC counts and a trend for higher BM blast percentage compared with DNMT3ALow ones, further strengthing a previous report by Narayanan et al.38that that DNMT3AHigh (≥44%) patients presented with leukocytosis and higher blast counts, and they further demonstrated that DNMT3A VAF had a positive correlations with WBC counts in AML patients.