In accordance with previous studies,9, 18, 19, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36 we detected DNMT3A mutations with a frequency of 20% in adult patients with primary CN‐AML, and most of the mutations clustered at the R882 site in exon 23. The gene discussed is DNMT3A; the disease is acute myeloid leukemia.