APOE‐ε4 prevalence (49.2% vs. 10.9%, P < 0.001) and core AD pathology (plaques: 12.70 vs. 1.03, P < 0.001; tangles: 9.79 vs. 5.54, P < 0.001) measures were significantly higher in participants with intermediate/high ADNC. The gene discussed is APOE; the disease is Alzheimer disease.