BRAF V600E mutant mCRC originating from the left‐side colon seemed to have superior overall survival compared with right‐side and rectal tumors, although statistical significance was not reached (median OS for left‐side, right‐side and rectal cancer: 20.4 m, 16.9 m, and 16.4 m, p = 0.296). This evidence concerns the gene BRAF and rectal neoplasm.