In Fig. 2C we highlight PHENSIM's predicted perturbation of a select set of affected pathways during infection, as recently identified to be of importance by Catanzaro et al. 2020 and Draghici et al. 2020 (also see Supplementary Figs. S1 and S2), such as IL-17, JAK-STAT and TNF signaling pathways, Toll-like Receptor (TLR), NOD-like receptor and RIG-I-like receptor signaling pathways as well as complement and coagulation cascades. This evidence concerns the gene TNF and infection.