CD4 and neoplasm: Interestingly, we found that DNMT1 and NSUN4 were moderately positively correlated with CD4+ T cells, natural killer cells, dendritic cells, and T helper cells; meanwhile, NSUN7 was weakly negatively correlated with MDSC and Tregs (Figure 8A), substantiating the close connection between the risk model based on the above three m5C regulatory genes and the tumor immune microenvironment.