CD4 and cancer: However, we found that the ratios of immunostimulatory/immunoinhibitory signatures (CD8+/CD4+ regulatory T cells, pro-/anti-inflammatory cytokines, and M1/M2 macrophages) were significantly higher in high-TMB than in low-TMB cancers (two-tailed Student’s t test, FDR < 0.1) in diverse cancer types (Figure 7B).