ROS1 and neoplasm: Based on the mutation status of the three genes, we defined the TMB prognostic score (TMBPS) as: TMBPS = - (a × mutated (ROS1) + b × mutated (SPEN) + c × mutated (PTPRT)), where a = -0.5071, b = -0.5189, and c = -0.3485, which were the coefficients of the three variables in the Cox proportional hazards model; mutated(X) = 1 if the gene X is mutated in the tumor sample, otherwise mutated(X) = 0.