Overexpression of autophagy related 14 (ATG14) can reverse the autophagy dysfunction of macrophages in ApoE-/- mice plaques, inhibit the accumulation of sequestosome 1 (SQSTM1)/P62, promote the differentiation of Tregs and up-regulate the number of Tregs, and reduce the inflammation and lesions of atherosclerosis (138). Here, SQSTM1 is linked to atherosclerosis.