Inhibition of serum/glucocorticoid regulated kinase 1 (SGK1) can reduce the translocation of factor forkhead box O1 (FoxO1) from the cytoplasm to the nucleus, ameliorate the Th17/Treg imbalance, and target organ damage to the heart and kidney in Ang II-induced hypertension mice (98). The gene discussed is SGK1; the disease is hypertensive disorder.