TNF and Sepsis: Septic HSV+ patients exhibited an increased duration of mechanical ventilation (Figure 1C) an increased length of hospital stay (Figure 1D), and showed higher SOFA scores (Figure 1E) resulting in increased mortality beyond day 14 after sepsis onset (Figure 1F), a time point in which septic patients exhibited markers of immunosuppression compared to healthy donors such as increased plasma IL-10 levels, unaltered plasma TNFα levels and reduced monocytic HLA-DR (Figure S1).