Furthermore, studies have shown that the polyglutamine binding protein 1 (PQBP1) in microglia first senses the exogenous tau 3R/4R proteins through direct interaction and then provokes innate immune reactions through triggering the cyclic GMP-AMP synthase (cGAS) in the stimulator of interferon gene (STING) pathway, while PQBP1 is required for sensing the tau-induced NF-KB translocation, NF-κB-dependent transcription of inflammatory genes, brain inflammation, and ultimately cognitive impairment in mice (110). Here, MAPT is linked to Cognitive impairment.