P2RX7 and neoplasm: Recent studies suggested that eATP activates P2X purinoceptor 7 (P2X7) expressed on macrophages, dendritic cells (DCs), granulocytes, T cells, and B cells to promote the formation of the NLRP3 inflammasome and the release of inflammatory cytokines such as IL-1β and IL-18 to enhance anti-tumor immunity (12–14).