SOCS3 and neoplasm: Using Reactome for pathway enrichment analyses (40), we observed Trp2Vax and immunotherapy treatment upregulated the IL-12 responsive genes, including ITGB1, SOCS3, IFNG and STAT4 in the tumor-infiltrating CD4+ T cells (with a False Discovery Rate, FDR= 0.0016) (Supplementary Figure 6H) (41).