Macrophages, in particular, demonstrate activation of additional Type I interferon responsive genes, including IFI209, IFI2712A, ISG15 and IFITM3 (FDR=10-5) (Figures 4D, E) (49), highlighting TA99-HL2-KOA1 may directly or indirectly through other cytokine mediators in the milieu engage innate immunity for anti-tumor responses. Here, ISG15 is linked to neoplasm.