In tumor-infiltrating macrophages we also observed increased activation of cytokine-responsive genes IFITM3, CCR1 and UBB (FDR=10-4), as well as upregulation of genes involved in MHC Class II presentation H2-Aa, H2-Ab1, H2-Eb1 and CD74 (FDR=0.0015) (Supplementary Figure 7C) (44). The gene discussed is UBB; the disease is neoplasm.