In oxazolone colitis, a murine model of UC which histologically resembles UC and is predominantly mediated by type-2 cytokines, it has been proposed that MAIT cell play a directly pathogenic role as disease severity is reduced in MR1-/- animals or with MR-1 antagonist isobutyl 6-formyl pterin (65). The gene discussed is MR1; the disease is colitis.