GPT and metabolic dysfunction-associated steatohepatitis: In response to HFD/WD feeding, fructose water and CCl4, NASH mice showed significantly increased body weight and serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) and triglyceride (TG) levels, especially in WD+F+CCl4 mice (Figure 1A).