With the daily administration of the LAB strain for 3 weeks in the early period of obesity, although there was no alteration found in body weight or fat mass, the expression of macrophage-specific chemokine CCL2 (Ccl2) and proinflammatory cytokine IL-1β (Il1b) decreased, suggesting that the LAB could alleviate the macrophage infiltration and inflammation of adipose tissue caused by obesity. This evidence concerns the gene IL1B and obesity due to melanocortin 4 receptor deficiency.