NOD1 (a main member of the NLRC) activation by FK-565 arouses systemic inflammation, with expanded PMN-MDSCs, followed by the later recruitment of M-MDSCs into the peritoneal compartment, and increases the expression of ARG1 to exert immunosuppressive function, thus driving carcinogenesis toward CRC (73). Here, ARG1 is linked to colorectal carcinoma.