SOCS1 and nasopharyngeal carcinoma: Moreover, independent of IFN production, STING overexpression in MDSCs upregulated the suppressor of cytokine signaling 1 (SOCS1), a potent inhibitor of Janus kinase (JAK) 1/2 in the JAK/STAT signaling pathway (121), preventing STAT3 phosphorylation (122, 123) and inhibiting the production and release of IL-6 and GM-CSF, two known drivers of MDSC expansion in nasopharyngeal carcinoma (7).