IL6 and neoplasm: Immune checkpoint protein V-domain immunoglobulin suppressor of T cell activation dampened the TLR-mediated activation of both MAPK/AP-1 and IKK/NF-κB signaling cascades and restored T cell IFN-γ production in mice bearing melanoma and increased the cytokines IL12p40, IL12p70, IL23p19, IL6, IFNβ, and TNFα as well as the chemokines CCL4, CCL5, CXCL9, and CXCL10 inside the tumor tissue (106).