A study indicated that LOX-1 (member of the Dectin-1 subgroup) was a specific marker for human PMN-MDSCs since LOX-1 could not be detected in the neutrophils of healthy donors, whereas LOX-1+ neutrophils (5–15% in cancer patients and 15–50% in tumor tissues) had potent immune suppressive activity and other biochemical characteristics of PMN-MDSCs (85). This evidence concerns the gene OLR1 and cancer.