LncRNA p53-stabilizing and activating RNA (PSTAR) can bind to hnRNP K and enhance its SUMOylation, thereby strengthening the interaction between hnRNP K and p53, ultimately resulting in the accumulation and transactivation of p53 to suppress hepatocellular carcinoma (Qin et al., 2020). The gene discussed is HNRNPK; the disease is hepatocellular carcinoma.