SUMOylation of DGCR8 is apparently related to the function of DGCR8 in regulating tumorigenesis and cell migration in lung adenocarcinoma (Figure 4A). The hnRNP K homology (KH)-type splicing regulatory protein (KHSRP) is one major component of the DROSHA complex. The gene discussed is DGCR8; the disease is lung adenocarcinoma.