LncRNA myosin heavy chain associated RNA transcript (MHRT) can regulate the SUMOylation levels of NAD-dependent protein deacetylase sirtuin-1 (SIRT1), peroxisome proliferator-activated receptor γ coactivator-1 α (PGC-1α)/peroxisome proliferator-activated receptor-α (PPARα), specificity protein 1 (SP1)/HDAC4 in cardiac hypertrophy (Liu et al., 2022). This evidence concerns the gene SP1 and cardiac hypertrophy.