As the samples of G1 patients were insufficient to participate in the analysis, the expression of immune checkpoints in the G2, G3, and G4 stages of ACC was analyzed, including SIGLEC15, TIGIT, CTLA4, CD274, HAVCR2, LAG3, PDCD1, and PDCD1LG2. The gene discussed is SIGLEC15; the disease is adrenal cortex carcinoma.