The results presented the expression of CASP3, GPX4, GSDME, and PRKACA was increased, while the expression of AIM2, CASP1, CASP4, CASP5, CASP8, CASP9, ELANE, GSDMA, GSDMB, GSDMD, IL1B, IL6, IL18, NLRC4, NLRP1, NLRP2, NLRP3, NLRP6, NOD1, NOD2, PJVK, PLCG1, SCAF11, TIRAP, and TNF was decreased in ACC. The gene discussed is NLRP3; the disease is adrenal cortex carcinoma.