IGFBP1 and polycystic ovary syndrome: A study by Shafiee et al. found that the expressions of IGF-1, insulin-like growth factor-binding protein 1 (IGFBP1), and phosphatase and tensin homolog (PTEN) genes were significantly upregulated in the endometrium of women with PCOS and endometrial cancer (EC) compared to their study controls.