As a result, miR-146 reduction in diabetes can cause excessive inflammation (due to inadequate inhibition of IRAK1/TRAF6), increased fibrosis (due to fibronectin overexpression), and increased MCP-1 production, followed by further reduction of miR-146a (due to enhanced TGF-β1/ErbB4/Notch1 signaling), which can eventually terminate in severe COVID-19 [70]. Here, IRAK1 is linked to diabetes mellitus.