Multivariate Cox regression and prognosis-related immune genes (ANGPTL4, IDO1, NOX1, CXCL3, LTB4R, IL1RL2, CD72, NOS2 and NUDT6) were used to construct an immune-related prognosis risk score model for colon adenocarcinoma patients. The gene discussed is ANGPTL4; the disease is colon adenocarcinoma.