C3 and age-related macular degeneration: Previous GWAS conducted in European populations has found that AMD was significantly associated with the variants among ARMS2-HTRA1, CFH, CFI, C2-CFB, C3, C9, VEGFA, APOE, LIPC, CETP, TIMP3, TNFRSF10A, COL8A1, SLC16A8, TGFBR1, RAD51B, ADAMTS9, and B3GALTL genes (Fritsche et al., 2016).