ARMS2 and age-related macular degeneration: Six SNPs with genome-wide significance (p < 5 × 10−8) were identified, including rs10490924, rs3750848, and rs3750846 in the ARMS2 locus and rs3793917, rs11200638, and rs2284665 in the HTRA1 locus (Table 1), suggesting that these SNPs of ARMS2 and HTRA1 were highly correlated with AMD development.