Besides, ELANE and LCN2 showed persistent increase except for the period from uncomplicated infection to sepsis and were associated with increased classical monocyte as well as decreased neutrophils and memory T cells, while IFI44 was only downregulated in septic shock and showed roughly the opposite correlations with immune cell fractions (Figures 6B, C). The gene discussed is LCN2; the disease is Sepsis.