(Lapointe et al., 2018) CRNDE could regulate the progression and chemoresistance of CRC via modulating the expression levels of miR-181a-5p and the activity of Wnt/β-catenin signaling (Han et al., 2017), and CRNDE attenuates chemoresistance in gastric cancer via SRSF6-regulated alternative splicing of PICALM (Zhang et al., 2021). The gene discussed is PICALM; the disease is gastric cancer.