Among them, (Chen et al., 2020), SNAI3-AS1 promoted the proliferation and metastasis of hepatocellular carcinoma by regulating the UPF1/Smad7 signaling pathway (Li et al., 2019b), and SNAI3-AS1 can also promote PEG10-mediated proliferation and metastasis by decoying miR-27a-3p and miR-34a-5p in hepatocellular carcinoma (Li et al., 2020). This evidence concerns the gene UPF1 and hepatocellular carcinoma.