To improve understanding of the correlation between TME and prognosis of cervical cancer, the present study assessed cervical cancer cell lines and tissues to reveal the roles of ERBB3 in the EMT induction of TME harboring immunosuppression, migration and invasion of cervical cancer, and to explore whether PI3K/AKT/mTOR signaling is involved in this process. This evidence concerns the gene PIK3CA and cervical cancer.