Among PD genes, one SNCA duplication, the LRRK2 R1441C founder mutation, and four novel heterozygous missense variants with unknown pathogenicity were detected; among AD genes, proven pathogenic missense mutations in PSEN1 and PSEN2 and two novel missense variants in PSEN2 and MAPT were detected. This evidence concerns the gene PSEN1 and Parkinson disease.