Although one of these risk loci is shared with AD (APOE) and two are shared with PD (SNCA and GBA), the most significantly associated SNP at the SNCA locus for PD was not significant for DLB (the association at the SNCA locus for DLB was mediated by a SNP at a different location), and a systematic assessment of other genetic loci previously associated with AD or PD showed no evidence of significant associations with DLB. The gene discussed is APOE; the disease is Alzheimer disease.