Among PD genes, one SNCA duplication, the LRRK2 R1441C founder mutation, and four novel heterozygous missense variants with unknown pathogenicity were detected; among AD genes, proven pathogenic missense mutations in PSEN1 and PSEN2 and two novel missense variants in PSEN2 and MAPT were detected. The gene discussed is LRRK2; the disease is Alzheimer disease.