On the contrary, GSTP1, known as a tumor suppressor in HCC,[29] is highly expressed in THLE2 and showed a strong CTCF binding peak proximal to GSTP1’s promoter along with extended CTCF and RNAPII mediated chromatin loops, but completely off in HepG2 (Figure 4E), implying the loss of this specific CTCF binding and associated chromatin loops that lead to a possible displacement of RNAPII during transformation from normal hepatocyte to HCC. The gene discussed is CTCF; the disease is hepatocellular carcinoma.