CTCF and hepatocellular carcinoma: This is in line with our previous report showing that genes proximal to the anchors of CTCF loops (CTCF anchor genes) were associated with active transcription.[14] For instance, MCF2L, an HCC‐specific gene (Figure S4F, Supporting Information), had specific CTCF binding/looping proximal to its promoter and is associated with considerable RNAPII binding/looping (Figure 4D) in HepG2 but absent in THLE2 cells.