We integrated the liver and liver disease‐related SNPs from GWAS and WGS data of HepG2 and THLE2 (Table S1, Supporting Information) but did not find significant contribution of non‐coding SNPs or small indels in the loci of CTCF binding sites or motifs near the TSSs of HCC‐associated genes (Figure S5A, Supporting Information), which motivated us to examine for potential epigenetic clue of differential CTCF binding. The gene discussed is CTCF; the disease is hepatocellular carcinoma.