To explore potential transcription factors that might be participated in specific E‐P interactions with HCC‐associated genes, we performed motif scan analysis using MEME[25] on 421 enhancers of HCC‐specific genes (Figure 2A), and identified a number of highly enriched consensus motifs of TF binding (Figure 2C), including the motif for the FOX family (e.g., FOXA1/FOXA2) involved in liver carcinogenesis.[26] Among them, the motif for Hepatocyte Nuclear Factor 4 family (HNF4G/HNF4A) is the most significantly enriched. This evidence concerns the gene FOXA2 and hepatocellular carcinoma.