As exemplified from the browser screenshot including 7 ENCODE cell lines derived from different type of cancers, the presence of the CTCF binding proximal to MCF2L promoter in HepG2 as compared to other six cancer cell lines is likely specific gain of function to HCC instead of some general cancer property, while the absence of the CTCF binding next to GSTP1 promoter in HepG2 may indicate a possible loss of function in HCC (Figure 4G). The gene discussed is CTCF; the disease is hepatocellular carcinoma.