To investigate if chromatin folding architectures are changed in HCC cells transformed from normal hepatocytes, we also performed CTCF ChIA‐PET experiments and characterized higher‐order chromatin compartment, chromatin domains, and chromatin loops mediated by CTCF and RNAPII in HepG2 and THLE2 cells using the ChIA‐PET datasets (Table S1, Supporting Information). The gene discussed is CTCF; the disease is hepatocellular carcinoma.