In line with the motif scan analysis, we found that HNF4G/HNF4A and FOXA1/FOXA2 are among the top 20 ranked TFs who's binding signals are significantly enriched in specific enhancers of HCC‐specific genes in HepG2 as in contrast to those enhancers of HCC‐suppressed genes (Figure 2D,E). The gene discussed is HNF4A; the disease is hepatocellular carcinoma.