To further validate the specific binding by these TFs in HepG2 at specific enhancers with E‐P interaction, we analyzed ENCODE ChIP‐seq data for 124 TFs in HepG2 cells (Table S5, Supporting Information) for TF binding signals at the genomic coordinates of the corresponding enhancers involved E‐P interaction with HCC‐specific genes and HCC‐suppressed genes. This evidence concerns the gene TF and hepatocellular carcinoma.