Roles for these two transcription factors in HCC have not been previously described, but supported by a recent study showing that HNF4A is upregulated in livers of nonalcoholic steatohepatitis (NASH) patients and positively correlated with nonalcoholic fatty liver disease (NAFLD) fibrosis score,[36] together suggesting HNF4A a central TF in the pathogenesis of NASH. The gene discussed is TF; the disease is hepatocellular carcinoma.