CTCF and cancer: To further validate the specificity of CTCF binding sites proximal to HCC‐associated genes, we integrated the CTCF ChIP‐seq data from ENCODE (Table S6, Supporting Information) and ascertained that these CTCF binding sites are indeed enriched as cell‐specific when compared to 29 ENCODE cancer cell lines (Figure 4F) and 70 non‐cancer cell lines (Figure S4G, Supporting Information).