In addition, applying the signatures of TAM subsets to TCGA CRC cohorts, we observed that the ratio of immunosuppressive macrophages (Macro‐c03‐Ifit3 and Macro‐c05‐Spp1) versus Cxcl9+Cxcl10+ macrophages (Macro‐c02‐Cxcl9) was associated with poor prognosis (Figure S5I, Supporting Information). The gene discussed is SPP1; the disease is colorectal carcinoma.