By comparison, Mono‐c03‐Vcan and Mono‐c04‐Ace were enriched in tumors (Figure S6D, Supporting Information) and similar to classical CD14hiCD16– and CD14+CD16hi monocytes in CRC patients, respectively (Figure S6C, Supporting Information).[14] Within the 5 macrophage clusters, only Macro‐c01‐Slc40a1 showed non‐cancer tissue preference, whereas the remaining clusters were enriched in tumors and thus denoted as TAMs (Figure S6B,D, Supporting Information). Here, CD14 is linked to colorectal carcinoma.