While anti‐PD‐1 increased Macro‐c02‐Sod2 and decreased Macro‐c03‐Ifit3 fractions in liver tumors, similar to the observations in SubQ‐only mice, anti‐PD‐1 failed to modulate macrophage subsets frequencies in SubQ sites of CSLT mice (Figure 4C), which might hamper effective anti‐tumor response in their SubQ tumors. This evidence concerns the gene IFIT3 and neoplasm.