The elevation of Macro‐05‐Spp1 was consistent with the increased fraction of SPP1+ macrophages in the liver metastasis of liver metastasized CRC patients.[42] Although anti‐PD‐1 reduced total macrophage populations at both SubQ and liver tumors in CSLT mice, macrophage subsets displayed distinct responses to the treatment. Here, PDCD1 is linked to colorectal carcinoma.