Compared to DC‐c04‐Cd209a, tumor‐infiltrating cDC2s (DC‐c03‐Ifit3) highly expressed activated (Cd83, Cd74, and H2‐Ab1), inflammatory (Isg15, Ly6a, Cxcl16, Fos and Junb) and inhibitory (Il1b and Il1r2) genes (Figure S6E, Supporting Information), suggesting that the phenotypes of cDC2s in tumors were heterogeneous and might be influenced by the TME. This evidence concerns the gene IL1B and neoplasm.