Altogether, our data suggested that tumors growing in the liver, which exhibited an immune tolerant environment, might increase fractions of pro‐tumor macrophage subsets including Macro‐c05‐Spp1 and Macro‐c03‐Ifit3 and impact their responses to PD‐1 blockade in multiple tumor sites of different organs. Here, IFIT3 is linked to neoplasm.