ISG15 and neoplasm: Furthermore, ANOVA tests on the tumor‐enriched clusters revealed that CD8‐c09‐Isg15, CD8‐c10‐Cd244, CD8‐c11‐Ccr7, CD8‐c12‐Gzmc, CD4‐c09‐Gzmb, Macro‐c03‐Ifit3, and NK‐c03‐Ccl5 were impacted by combined effects of liver tumors and anti‐PD‐1 treatment (Figure 5G).