Abnormal activation of STAT3 also leads to abnormal overexpression of various proteins, including Mcl-1, Bcl-2, Bcl-xl, survivin, Cyclin D1, c-Myc, and VEGF, which leads to tumor development (Gao et al., 2005; Verma et al., 2010). The gene discussed is STAT3; the disease is neoplasm.