Ruan et al. found that overexpression of OCT4 (a marker for cancer stem cells in ovarian cancer) increased the activation of the JAK/STAT pathway, especially JAK1 and STAT6, and promoted the translocation of STAT6 from the cytoplasm to nuclear in non-SP cells (CSC-like side population cells), thereby increasing the expression of Cyclin D1, c-Myc, and Bcl-2 (Gough et al., 2013; Ruan et al., 2019). This evidence concerns the gene STAT6 and cancer.