When studying the tumor suppression of m6A reader YTHDC2 in lung adenocarcinoma, Ma et al. also found that the PDX model of lung adenocarcinoma was sensitive to ferroptosis inducers because SLC7A11 (the catalytic subunit of system XC-) was a direct target of YTHDC2, which inhibited cystine uptake (Ma et al., 2021). Here, SLC7A11 is linked to lung adenocarcinoma.