The variant NSD3 (T1232A) of the methyltransferase NSD3 caused the expression of nearby oncogenes, such as FGFR1, to be turned on by dimethylation of histone H3 lysine 36 (H3K36), which in turn drives the progression of lung squamous cell carcinoma. The gene discussed is NSD3; the disease is squamous cell lung carcinoma.