In the present study, the expression levels of IL-1β, IL-6, and TNF-α were significantly increased in the LPS group, which was in agreement with histological findings; red/NIR LED irradiation significantly inhibited the secretion of these pro-inflammatory cytokines, demonstrating that red/NIR LED irradiation could treat OM by impeding pro-inflammatory cytokine release. Here, TNF is linked to ocular melanoma.