Growth- and proliferation-related enrichment results were found in both adolescent and adult MDD patients, such as: mitogen-activated protein kinase (MAPK) pathway, phosphatidylinositol 3'-kinase (PI3K)-Akt pathway, mammalian target of rapamycin (mTOR) pathway, mitotic cell cycle process, developmental cell growth, and positive regulation of developmental growth. Here, AKT1 is linked to major depressive disorder.