The lack of PPM1D in the mouse model increased the release of inflammatory cytokines in the brain, increased the number of activated microglia and macrophages in the brain, aggravated brain tissue lesions, and aggravated cognitive impairment, which proved that it was a key neuroprotective agent to prevent brain damage caused by a hypoxic inflammatory response (46). This evidence concerns the gene PPM1D and Cognitive impairment.