We searched for the KEGG information of the 12 genes on the KEGG webpage (https://www.kegg.jp/) and found only two pathways information for IPO7: nucleocytoplasmic transport and MAPK signaling pathway; 5 pathways information for MAP2K5: MAPK signaling pathway, gap junction, neurotrophin signaling pathway, oxytocin signaling pathway, fluid shear stress and atherosclerosis; and one pathway information for PPM1D: p53 signaling pathway. The gene discussed is PPM1D; the disease is atherosclerosis.