Some have also been found in a depression-related immune studies, such as IL4, IL10, IL18, CSF2R, IFNGR1, CCL2, LTA, PRKCSH, PSMD13, IDO1, FKBP4 (20), which echoed the acute immune inflammatory response immediately after electroconvulsive treatment in patients with depression (21), indicating that immunity may play an important role in patients with depression. Here, IL18 is linked to depressive disorder.