CSF3 and neoplasm: However, in chronic inflammatory conditions such as cancer, tumor, and/or stroma-derived factors including MCSF, IL6, VEGF, GCSF, and others, reprogram myelopoiesis (7) leading to development of tumor-promoting phagocytes such as Neut/myeloid-derived suppressor cells (MDSC), tumor-associated MFs (TAM), and immature DCs (8, 9).