AR is an IgE-mediated type I hypersensitivity reaction that is characterized by increased vascular permeability, increased mast cells and related inflammatory cell secretion of histamine, leukotriene, and other inflammatory mediators, occurrence of mucosal edema and exudation, obstruction of the ET, and decreased cilia motility, resulting in OME. The gene discussed is IGHE; the disease is IgE responsiveness, atopic.