The top 3 publications with the highest citations were all published in Science (IF: 63.832), entitled “Gut microbiome influences efficacy of PD-1-based immunotherapy against epithelial tumors” by Routy Bertrand, which was the most cited reference with 2,339 citations (28), followed by “Commensal Bifidobacterium promotes antitumor immunity and facilitates anti-PD-L1 efficacy” with 2,069 citations (29) and “Gut microbiome modulates response to anti-PD-1 immunotherapy in melanoma patients” with 2,010 citations (30). The gene discussed is CD274; the disease is melanoma.