identified withaferin A (WA), a natural ferritin inducer in neuroblastoma, to inhibit neuroblastoma cell appreciation as well as inhibit the growth and recurrence of murine neuroblastoma heterogeneous tumors by inhibiting GPX4 or targeting Keap1 to increase the unstable iron pool, which in turn suggested a new therapeutic strategy by iron induction to kill cancer cells effectively. The gene discussed is GPX4; the disease is neuroblastoma.