GPX4 and glioblastoma: constructed a nano drug (FA/Pt-si-GPX4@IONPs) based on the specific pathophysiological characteristics of glioblastoma (GBM), which is based on porous iron oxide nanoparticles (IONPs) that carry cisplatin (Pt) and small interfering RNA (si-GPX4) inside, and the surface of the drug-carrying IONPs is modified with Folic acid, which can bind to the highly expressed folate receptor on the surface of glioma (96).