The causal estimates for VEGF on the risk of brain glioblastoma (IVW: OR = 1.278, 95% CI, 0.463~3.528, P = 0.636) and malignant neoplasm of meninges (IVW: OR = 0.831, 95% CI, 0.486~1.421, P = 0.499) were basically consistent with the above findings. The gene discussed is VEGFA; the disease is brain glioblastoma.