The causal estimates for brain glioblastoma (IVW: β = 0.010, 95% CI, -0.002~0.022, P = 0.108) and malignant neoplasm of meninges (IVW: β= 0.010, 95% CI, -0.030~0.050, P = 0.618) on VEGF were similar to those described above. This evidence concerns the gene VEGFA and brain glioblastoma.