ALK and non-small cell lung carcinoma: Comparatively, in the upfront setting, a review of 39 treatment naïve patients with ALK+ NSCLC with BM in the PROFILE 1014 study showed improved results with an icORR of 77%, icDCR of 85% and 56% at 12 weeks and 24 weeks, respectively, and time to intracranial progression of 15.7 months (69).