CRLF2 and acute lymphoblastic leukemia: Further markers include CD58, that is usually overexpressed in ALL cases (17), and antigens associated with genetic lesions such as CD123 (hyperdiploidy), CD66c (hyperdiploidy and BCR/ABL), NG2 (MLL-rearrangements), CRLF2 (CRLF2-rearrangements), and lack of CD44 positivity (TEL/AML1 and B-ALL with MYC-translocation) (18).